BDBM50505846 CHEMBL4562138::US12522615, Example I-003

SMILES C[C@@H]1CCCOc2c(cnn2C)-c2cc(cc(C)n2)C(=O)\N=C2/Nc3ccccc3N2C1

InChI Key InChIKey=KHVDGZRHSTVJLQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50505846   

TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 50505846BDBM50505846(CHEMBL4562138 | US12522615, Example I-003)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 50505846BDBM50505846(CHEMBL4562138 | US12522615, Example I-003)
Affinity DataIC50: 900nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Mouse)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505846BDBM50505846(CHEMBL4562138 | US12522615, Example I-003)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed