BDBM50505946 CHEMBL4565615::US11168095, Example 138

SMILES C[C@H]1CCCn2cnnc2-c2cccc(NC(=O)c3ccccc3O1)n2

InChI Key InChIKey=RLJLYJODLXFSPU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50505946   

LigandPNGBDBM50505946(CHEMBL4565615 | US11168095, Example 138)
Affinity DataIC50: 165nMAssay Description:Inhibition of human ASK1 using myelin basic protein substrate pre-incubated for 20 mins before [33P]-ATP addition and measured after 2 hrs by filter-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50505946(CHEMBL4565615 | US11168095, Example 138)
Affinity DataIC50: 550nMAssay Description:Table 2: Alternatively, the protein kinase activity of the compounds described herein were tested using the ASK1/MAP3K5 assay by Reaction Biology Cor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

LigandPNGBDBM50505946(CHEMBL4565615 | US11168095, Example 138)
Affinity DataIC50: 969nMAssay Description:Inhibition of V5 tagged human ASK1 expressed in HEK-293T cells assessed as reduction in T838 autophosphorylation incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed