BDBM50506983 CHEMBL4529533

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(c2)C(C)(C)O)n(CC=C)c3=O)cc1

InChI Key InChIKey=AUXJOVLMVFCZLM-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50506983   

TargetWee1-like protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50506983(CHEMBL4529533 | US12220415, Compound CM-169)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant Wee1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50506983(CHEMBL4529533 | US12220415, Compound CM-169)
Affinity DataIC50: 6.90nMAssay Description:A LanthaScreen kinase activity assay was conducted to assess WEE1 kinase inhibitory activity for compounds of this disclosure. LanthaScreen Eu time-r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50506983(CHEMBL4529533 | US12220415, Compound CM-169)
Affinity DataKi:  470nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50506983(CHEMBL4529533 | US12220415, Compound CM-169)
Affinity DataKi:  600nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50506983(CHEMBL4529533 | US12220415, Compound CM-169)
Affinity DataKi:  603nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50506983(CHEMBL4529533 | US12220415, Compound CM-169)
Affinity DataIC50: 1.34E+3nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50506983(CHEMBL4529533 | US12220415, Compound CM-169)
Affinity DataIC50: 4.94E+3nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed