BDBM50507139 CHEMBL4446104

SMILES COc1ccc(\C=N\Nc2nc(cs2)-c2c3OC4=CC(O)=C(C(C)=O)C(=O)[C@]4(C)c3c(O)c(C)c2O)cc1

InChI Key InChIKey=GBQFTCXONCOLDN-ZNDVKXBSSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50507139   

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Siberian Branch of The Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50507139(CHEMBL4446104)
Affinity DataKd:  8.65E+3nMAssay Description:Binding affinity to recombinant human Tdp1 (149 to 608 residues) expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Siberian Branch of The Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50507139(CHEMBL4446104)
Affinity DataIC50:  158nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed