BDBM50507449 CHEMBL4453071

SMILES Oc1cccc(F)c1N1CCc2c(C1)ncnc2N1CCN(CC1)C(=O)C=C

InChI Key InChIKey=QQDZUWAWAYTSOU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50507449   

TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50507449(CHEMBL4453071)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation measured after 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed