BDBM50507709 CHEMBL4438236
SMILES Cc1ccc(cc1NC(=O)C1(CC1)c1ncnc2[nH]ccc12)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
InChI Key InChIKey=JLJLHDXHENENSD-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50507709
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human GST-tagged BRAF V600E mutant (416 to 766 residues) using human full length 6His-tagged MEK1 (K97R) as substrate preincubated for ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of cRAF (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair