BDBM50508013 CHEMBL4541479

SMILES CCOc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(c2n1)S(C)(=O)=O)C(=O)N1CCC(CC1)N1CCN(C)CC1

InChI Key InChIKey=HTFNVAVTYILUCF-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50508013   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataKd:  3.60E+3nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50:  8nMAssay Description:Inhibition of ERK5 in human HeLa cells by KiNativ profiling methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to human BRD4 BD1 (44 to 168 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50:  20nMAssay Description:Inhibition of His-tagged MAP2K5 activated N-terminal GST-tagged recombinant human ERK5 (1 to 398 residues) expressed in Escherichia coli using biotin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50:  8nMAssay Description:Inhibition of ERK5 (unknown origin) incubated for 1 hr by KiNativ profiling analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50:  86nMAssay Description:Inhibition of ERK5 in human SN12C cells transduced with MEF2-responsive transcription element assessed as reduction in MEF2 transcription by measurin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed