BDBM50510347 CHEMBL4475244

SMILES COc1nc2ccc(cc2c(Cl)c1CC(F)(F)F)C(O)(c1cnnn1C)c1ccc(C)nc1C

InChI Key InChIKey=PYLOODPJFPYIJW-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50510347   

TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510347(CHEMBL4475244)
Affinity DataKd:  2.90nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510347(CHEMBL4475244)
Affinity DataIC50: 45nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed