BDBM50510357 CHEMBL4543938

SMILES COc1nc2ccc(cc2c(Cl)c1CN1CCC(CC1)C(F)(F)F)C(O)(c1cnnn1C)c1ccnc(c1)C(F)(F)F

InChI Key InChIKey=ATAMYSLQMJYOMH-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50510357   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510357(CHEMBL4543938)
Affinity DataIC50:  12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510357(CHEMBL4543938)
Affinity DataKd:  1.30nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510357(CHEMBL4543938)
Affinity DataIC50:  8nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed