BDBM50510358 CHEMBL4459199

SMILES COc1nc2ccc(cc2c(Cl)c1CN1CCC(CC1)C(F)(F)F)C(O)(C1CN(C1)C(C)=O)c1cnc(C)n1C

InChI Key InChIKey=FJZJAZBCXLUXBG-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50510358   

TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510358(CHEMBL4459199)
Affinity DataKd:  4.80nMAssay Description:Displacement of thermofluor from human recombinant N-terminal TEV cleavage site-fused-His-tagged RORgammat LBD expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510358(CHEMBL4459199)
Affinity DataIC50: 313nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed