BDBM50510991 CHEMBL4564735

SMILES NC1=N[C@@]2(CO1)c1cc(ccc1Oc1c(F)nc(cc21)C1=CCCOC1)-c1cccnc1F

InChI Key InChIKey=JAZOCUNZCUBRJX-DEOSSOPVSA-N

Data  5 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50510991   

TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50510991(CHEMBL4564735)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACE1 (unknown origin) using FRET peptide substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBeta-secretase 2(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50510991(CHEMBL4564735)
Affinity DataEC50:  40nMAssay Description:Inhibition of BACE2 in mouse B16-F1 cells assessed as increase in intracellular PMEL17 Mbeta accumulation measured after 4 days by Western blot analy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50510991(CHEMBL4564735)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of BACE2 (unknown origin) using FRET peptide substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50510991(CHEMBL4564735)
Affinity DataIC50:  93nMAssay Description:Inhibition of recombinant CatD (unknown origin) expressed in CHO cells using FRET peptide substrate preincubated for 1 hr followed by substrate addit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50510991(CHEMBL4564735)
Affinity DataIC50:  75nMAssay Description:Inhibition of cathepsin E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50510991(CHEMBL4564735)
Affinity DataIC50:  56nMAssay Description:Inhibition of recombinant human BACE2 expressed in HEK293 cells co-transfected with N-terminal HA-tagged/C-terminal Myc tagged Mbeta chain of human P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed