BDBM50511204 CHEMBL4463341

SMILES Cc1cc(CNc2cccc(c2)C(O)=O)ccc1OCc1ccc(F)cc1

InChI Key InChIKey=DDCNGNDFKHLAQY-UHFFFAOYSA-N

Data  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50511204   

TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Oklahoma

Curated by ChEMBL
LigandPNGBDBM50511204(CHEMBL4463341)
Affinity DataEC50:  37nMAssay Description:Agonist activity at human PPARalpha expressed in nonhuman mammalian cells assessed as increase in receptor transcriptional activity incubated for 22 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Oklahoma

Curated by ChEMBL
LigandPNGBDBM50511204(CHEMBL4463341)
Affinity DataEC50:  93nMAssay Description:Binding affinity to PPARalpha in human MIO-M1 cells assessed as increase in thermal stability preincubated for 3 hrs followed by exposure to 45.5 deg...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
University of Oklahoma

Curated by ChEMBL
LigandPNGBDBM50511204(CHEMBL4463341)
Affinity DataKd:  140nMAssay Description:Binding affinity to His-tagged PPARalpha LBD (unknown origin) expressed in Escherichia coli Rosetta (DE3) at 25 degree C by isothermal titration calo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed