BDBM50511686 CHEMBL4468733

SMILES NC(=O)c1ccc(cc1)-c1cnn2ccc(NCc3ccccn3)nc12

InChI Key InChIKey=OSHIEAFPXASVQE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50511686   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50511686(CHEMBL4468733)
Affinity DataIC50:  44nMAssay Description:Inhibition of recombinant N-Terminal GST-tagged human RET V804M mutant (658 to end residues) incubated for 15 mins followed by substrate addition and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50511686(CHEMBL4468733)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of RET V804M mutant (unknown origin)expressed in human BaF3 cells assessed as reduction in cell viability incubated for 48 hrs by celltite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed