BDBM50512918 CHEMBL4458304

SMILES Cc1nn(C)cc1NC(=O)[C@@H]1[C@H]2CC[C@H](CC2)[C@H]1C(=O)c1ccc(-c2cc[nH]n2)cc1F

InChI Key InChIKey=LSHBRESJOLLYTF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50512918   

LigandChemical structure of BindingDB Monomer ID 50512918BDBM50512918(CHEMBL4458304)
Affinity DataIC50: 63nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50512918BDBM50512918(CHEMBL4458304)
Affinity DataIC50: 200nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in calcium ionophore-stimulated LTB4 production preincubated for 30 mins followed by ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed