BDBM50512975 CHEMBL4471748

SMILES CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2ccccc2)C1

InChI Key InChIKey=JRIBEBYKWORBGC-UHFFFAOYSA-N

Data  1 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50512975   

TargetHistone acetyltransferase KAT2B(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512975BDBM50512975(CHEMBL4471748)
Affinity DataIC50: 41nMAssay Description:Inhibition of biotinylated peptide binding to human GST-tagged PCAF bromodomain expressed in Escherichia coli Rosetta (DE3) measured after 15 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512975BDBM50512975(CHEMBL4471748)
Affinity DataKd:  152nMAssay Description:Binding affinity to human N-terminal His-tagged PCAF by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50512975BDBM50512975(CHEMBL4471748)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity N-terminal his tagged wild type human SETDB1 (190 to 410 residues ) expressed in Escherichia coli BL21 (DE3) assessed as dissociatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)