BDBM50513563 CHEMBL4470581

SMILES COc1cc(ccc1Nc1cc(ccn1)N1CCC[C@@H](C1)C(=O)NCc1ccc(OC(F)(F)F)cc1)N1CCN(C)CC1

InChI Key InChIKey=OBAHAQPVDNQTSJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50513563   

TargetALK tyrosine kinase receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50513563(CHEMBL4470581)
Affinity DataIC50: 492nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK (catalytic domain 1058 - 1620 residues) expressed in baculovirus system assessed as decreas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50513563(CHEMBL4470581)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROS1 (catalytic domain 1883 - 2347 residues) expressed in baculovirus system assessed as decrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed