BDBM50514032 CHEMBL4471831

SMILES Fc1ccc-2c(c1)C(=O)c1nc3ccc(cc3c(=O)n-21)N1CCNCC1

InChI Key InChIKey=RPUURHIUQGSCQG-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50514032   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514032(CHEMBL4471831)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed as reduction in conversion of L-tryptophan to N-formyl kynuren...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514032(CHEMBL4471831)
Affinity DataIC50: 3.15E+3nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of L-tryptophan to N-formyl kynureni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514032(CHEMBL4471831)
Affinity DataIC50: 760nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production incubated for 18 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514032(CHEMBL4471831)
Affinity DataIC50: 290nMAssay Description:Inhibition of human TDO transfected in HEK293 cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 12 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514032(CHEMBL4471831)
Affinity DataIC50: 4.16E+4nMAssay Description:Inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514032(CHEMBL4471831)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibition of human IDO2 transfected in human U87MG cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514032(CHEMBL4471831)
Affinity DataKi:  670nMAssay Description:Mixed uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514032(CHEMBL4471831)
Affinity DataKi:  6.08E+3nMAssay Description:Uncompetitive inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed inhibition constant using varying concentration ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514032(CHEMBL4471831)
Affinity DataKi:  3.69E+4nMAssay Description:Uncompetitive inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed