BDBM50514308 CHEMBL4448899
SMILES Cc1c(NC(=O)c2cc(nc3cc(F)ccc23)C(N)=O)c(nn1Cc1ccc(cc1)C#N)C(F)(F)F
InChI Key InChIKey=BKLJDIJJOOQUFG-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50514308
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human GLUT1 expressed in DLD1 cells assessed as glucose uptake by measuring ATP incubated for 15 mins by CellTiter-Glo Luminescent Cell...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human GLUT1 expressed in CHO-K1 cells constitutively expressing luciferase using luciferin substrate measured after 10 mins by lucifera...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human GLUT1 expressed in human DLD-1 cells assessed as reduction in glucose uptake by measuring decrease in ATP production incubated fo...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GLUT1 in human HEY cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintillation...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GLUT1 in human OVCAR-3 cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintilla...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GLUT1 in human SK-OV-3 cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintilla...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GLUT1 in human OVCA-432 cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintill...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GLUT1 in human OVCR-429 cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintill...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 4(Human)
University of Glasgow
Curated by ChEMBL
University of Glasgow
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human GLUT4 expressed in CHO cells measured after 15 mins by cell-titer-Glo luminescent cell viability assayMore data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 4(Human)
University of Glasgow
Curated by ChEMBL
University of Glasgow
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of human GLUT4 expressed in CHO cells assessed as reduction in glucose uptake by measuring decrease in ATP production preincubated for 20 ...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 3(Human)
Bayer AG
Curated by ChEMBL
Bayer AG
Curated by ChEMBL
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of human GLUT3 expressed in human GLUT1-/- DLD-1 cells assessed as reduction in glucose uptake by measuring decrease in ATP production inc...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 3(Human)
Bayer AG
Curated by ChEMBL
Bayer AG
Curated by ChEMBL
Affinity DataIC50: 4.81E+3nMAssay Description:Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 2(Human)
Bayer AG
Curated by ChEMBL
Bayer AG
Curated by ChEMBL
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of human GLUT2 expressed in CHO cells assessed as reduction in fructose uptake by measuring decrease in ATP production incubated for 15 mi...More data for this Ligand-Target Pair