BDBM50514308 CHEMBL4448899
SMILES Cc1c(NC(=O)c2cc(nc3cc(F)ccc23)C(N)=O)c(nn1Cc1ccc(cc1)C#N)C(F)(F)F
InChI Key InChIKey=BKLJDIJJOOQUFG-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50514308
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University
Curated by ChEMBL
Southern Medical University
Curated by ChEMBL
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University
Curated by ChEMBL
Southern Medical University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human GLUT1 expressed in DLD1 cells assessed as glucose uptake by measuring ATP incubated for 15 mins by CellTiter-Glo Luminescent Cell...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University
Curated by ChEMBL
Southern Medical University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human GLUT1 expressed in CHO-K1 cells constitutively expressing luciferase using luciferin substrate measured after 10 mins by lucifera...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University
Curated by ChEMBL
Southern Medical University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human GLUT1 expressed in human DLD-1 cells assessed as reduction in glucose uptake by measuring decrease in ATP production incubated fo...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University
Curated by ChEMBL
Southern Medical University
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GLUT1 in human HEY cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintillation...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University
Curated by ChEMBL
Southern Medical University
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GLUT1 in human OVCAR-3 cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintilla...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University
Curated by ChEMBL
Southern Medical University
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GLUT1 in human SK-OV-3 cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintilla...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University
Curated by ChEMBL
Southern Medical University
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GLUT1 in human OVCA-432 cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintill...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University
Curated by ChEMBL
Southern Medical University
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GLUT1 in human OVCR-429 cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintill...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University
Curated by ChEMBL
Southern Medical University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 4(Human)
University of Glasgow
Curated by ChEMBL
University of Glasgow
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human GLUT4 expressed in CHO cells measured after 15 mins by cell-titer-Glo luminescent cell viability assayMore data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 4(Human)
University of Glasgow
Curated by ChEMBL
University of Glasgow
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of human GLUT4 expressed in CHO cells assessed as reduction in glucose uptake by measuring decrease in ATP production preincubated for 20 ...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 3(Human)
Bayer AG
Curated by ChEMBL
Bayer AG
Curated by ChEMBL
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of human GLUT3 expressed in human GLUT1-/- DLD-1 cells assessed as reduction in glucose uptake by measuring decrease in ATP production inc...More data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 3(Human)
Bayer AG
Curated by ChEMBL
Bayer AG
Curated by ChEMBL
Affinity DataIC50: 4.81E+3nMAssay Description:Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 2(Human)
Bayer AG
Curated by ChEMBL
Bayer AG
Curated by ChEMBL
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of human GLUT2 expressed in CHO cells assessed as reduction in fructose uptake by measuring decrease in ATP production incubated for 15 mi...More data for this Ligand-Target Pair