BDBM50514378 CHEMBL4450657

SMILES C=CC(=O)N1CCN(c2nc(=O)n(-c3ccccc3C(C)C)c3nc(-c4c(O)cccc4F)c(Cl)cc23)[C@@H](C)C1

InChI Key InChIKey=PLWUHRVBTOATQZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50514378   

TargetGTPase KRas(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514378BDBM50514378(CHEMBL4450657)
Affinity DataIC50: 44nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514378BDBM50514378(CHEMBL4450657)
Affinity DataIC50: 51nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed