BDBM50514389 CHEMBL4439782

SMILES C=CC(=O)N1CCN(c2nc(=O)n(-c3ccccc3C(C)C)c3nc(-c4c(O)cccc4F)c(Cl)cc23)CC1

InChI Key InChIKey=UMMHCXMLOADCEX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50514389   

TargetGTPase KRas(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514389BDBM50514389(CHEMBL4439782)
Affinity DataIC50: 69nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed