BDBM50516388 CHEMBL4453232

SMILES Fc1cccc(Cl)c1C(=O)c1c[nH]c(c1)C(=O)Nc1cccnc1

InChI Key InChIKey=PZZAQNIXGLXSPW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50516388   

TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516388(CHEMBL4453232)
Affinity DataIC50:  600nMAssay Description:Inhibition of recombinant N-terminal His-tagged human ERK5 (2 to 409 residues) co-expressed with GST-tagged human truncated MEK5DD lacking N-terminal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516388(CHEMBL4453232)
Affinity DataIC50:  700nMAssay Description:Inhibition of human recombinant N-terminal His-tagged / TEV cleavage site fused ERK5 (2 to 409 residues) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516388(CHEMBL4453232)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of HA-tagged ERK5 (unknown origin) coexpressed with mutationally activated EGFP-MEK5D and Gal4-MEF2D in HEK293 cells assessed as reduction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516388(CHEMBL4453232)
Affinity DataIC50:  9.32E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full length human p38alpha expressed in Escherichia coli cells assessed as substrate phosphorylation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed