BDBM50517239 CHEMBL4441401

SMILES C=CC(=O)N1CCN(c2ncnc3c2CCC(c2c(C)ccc4[nH]ncc24)C3)[C@@H](C)C1

InChI Key InChIKey=MBPPZCHPUVJHGP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50517239   

TargetGTPase KRas(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50517239BDBM50517239(CHEMBL4441401)
Affinity DataIC50: 4.86E+3nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as increase in accumulation of GDP bound KRAS G12C mutant protein incubated for 6 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed