BDBM50518022 CHEMBL4458783

SMILES Cc1ccc(CSc2nnc(-c3ccccn3)n2Cc2ccco2)cc1C(F)(F)F

InChI Key InChIKey=OQJGZGAYSCWFCK-UHFFFAOYSA-N

Data  3 KI  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50518022   

TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataEC50:  31nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 1 hrs by TopCou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataEC50:  31nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataEC50:  329nMAssay Description:Agonist activity at human kappa opioid receptor expressed in human U2OS cells assessed as increase in ERK1/2 phosphorylation after 10 mins by Western...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataKi:  1.90E+3nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataEC50:  3.14E+3nMAssay Description:Agonist activity at human kappa opioid receptor expressed in human U2OS cells co-transfected with GFP and beta-arrestin-2 assessed as increase in bet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataEC50:  4.13E+3nMAssay Description:Agonist activity at human kappa opioid receptor expressed in human U2OS cells co-transfected with EFC and beta-arrestin-2 assessed as increase in bet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataEC50:  4.13E+3nMAssay Description:Inhibition of kappa opioid receptor (unknown origin) assessed as increase in beta arrestin 2 recruitmentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50518022(CHEMBL4458783)
Affinity DataKi:  5.35E+3nMAssay Description:Binding affinity to DOR (unknown origin) assessed as inhibition constant by ratio ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed