BDBM50518516 CHEMBL4445116

SMILES CC(C)(CC#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O)C#N

InChI Key InChIKey=UDHXHJAZPMOTOA-LBPRGKRZSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50518516   

LigandPNGBDBM50518516(CHEMBL4445116)
Affinity DataEC50:  90nMAssay Description:Inhibition of PIM in human KG1 cells assessed as reduction in pS6 levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-1(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518516(CHEMBL4445116)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase pim-2(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518516(CHEMBL4445116)
Affinity DataIC50:  29nMAssay Description:Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM50518516(CHEMBL4445116)
Affinity DataIC50:  3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed