BDBM50518524 CHEMBL4563683

SMILES Cc1ccc(Cn2cc(COc3cc4ncnc(Nc5ccc(F)c(Cl)c5)c4cc3NC(=O)C=C)nn2)cc1

InChI Key InChIKey=AFWYYXKXLMISDO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50518524   

TargetEpidermal growth factor receptor(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518524(CHEMBL4563683)
Affinity DataIC50: 15nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR T790M/L858R double mutant (696 to end residues) expressed in baculovirus infected sf21 cells using pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518524(CHEMBL4563683)
Affinity DataIC50: 105nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR kinase domain (696 to end residues) expressed in baculovirus infected sf21 cells using poly(Glu, Tyr) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518524(CHEMBL4563683)
Affinity DataIC50: 158nMAssay Description:Inhibition of human C-terminal His6-tagged ERBB2 (676 to end residues) expressed in baculovirus infected sf21 cells using poly(Glu, Tyr) 4:1 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed