BDBM50518528 CHEMBL4476544

SMILES OCCCn1cc(COc2cc3ncnc(Nc4ccc(F)c(Cl)c4)c3cc2NC(=O)C=C)nn1

InChI Key InChIKey=RFSXIPRAZZPVFM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50518528   

TargetEpidermal growth factor receptor(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518528(CHEMBL4476544)
Affinity DataIC50: 4nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR T790M/L858R double mutant (696 to end residues) expressed in baculovirus infected sf21 cells using pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518528(CHEMBL4476544)
Affinity DataIC50: 12nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR kinase domain (696 to end residues) expressed in baculovirus infected sf21 cells using poly(Glu, Tyr) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518528(CHEMBL4476544)
Affinity DataIC50: 67nMAssay Description:Inhibition of human C-terminal His6-tagged ERBB2 (676 to end residues) expressed in baculovirus infected sf21 cells using poly(Glu, Tyr) 4:1 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed