BDBM50521244 CHEMBL4525398

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1cc(C)ncn1)[C@H]2Nc1nc2N(CCCn2n1)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=DUPCKWLECUXWCT-UPHUGPLXSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50521244   

TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50521244(CHEMBL4525398)
Affinity DataIC50:  11nMAssay Description:Modulation of gamma secretase in human H4 cells overexpressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in tota...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50521244(CHEMBL4525398)
Affinity DataEC50:  0.0117nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed