BDBM50521925 CHEMBL4529532

SMILES C[C@@H]1CCCCn2ncc(c12)-c1nc(Nc2ccc(cn2)N2CC3(CN(CCCF)C3)C2)ncc1F

InChI Key InChIKey=JSCXSRGTJHDPTA-GOSISDBHSA-N

Data  3 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50521925   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Genentech

Curated by ChEMBL

LigandBDBM50521925(CHEMBL4529532)Copy SMILESCopy InChI

Affinity DataKi: <0.300nMAssay Description:Inhibition of human full length GST-tagged CDK4 (1 to 303(end) amino acids)/Cyclin D3 (1 to 292(end) amino acids) expressed in baculovirus expression...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Genentech

Curated by ChEMBL

LigandBDBM50521925(CHEMBL4529532)Copy SMILESCopy InChI

Affinity DataKi:  3.30nMAssay Description:Inhibition of human full length GST-tagged CDK6 (1 to 326(end) amino acids)/Cyclin D3 (1 to 292(end) amino acids) expressed in baculovirus expression...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM50521925(CHEMBL4529532)Copy SMILESCopy InChI

Affinity DataKi:  110nMAssay Description:Inhibition of human recombinant full length GST-tagged CDK1/Cyclin A2 expressed in sf9 insect cells assessed as inhibition constant using Ulight-4E-B...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI
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