BDBM50523706 CHEMBL4542639

SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)c3ccc(Cl)c(c3)C(F)(F)F)cc2)ccc1N

InChI Key InChIKey=WHMDUJXKQMEJCM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50523706   

TargetSerine/threonine-protein kinase B-raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50523706(CHEMBL4542639)
Affinity DataIC50:  73nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged BRAF V600E mutant catalytic domain (416 to 766 residues) expressed in baculovirus expression sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50523706(CHEMBL4542639)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of recombinant full-length human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using Fluor-de-Lys as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50523706(CHEMBL4542639)
Affinity DataIC50:  73nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50523706(CHEMBL4542639)
Affinity DataIC50:  92nMAssay Description:Inhibition of human CRAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Human)
Menoufia University

Curated by ChEMBL
LigandPNGBDBM50523706(CHEMBL4542639)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50523706(CHEMBL4542639)
Affinity DataIC50:  183nMAssay Description:Inhibition of human ARAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed