BDBM50524484 CHEMBL187262::US12528773, Example NB-DNJ, miglustat

SMILES CCCC[N@@]1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O

InChI Key InChIKey=UQRORFVVSGFNRO-UHFFFAOYSA-N

Data  2 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50524484   

TargetNon-lysosomal glucosylceramidase(Rat)
Alectos Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50524484BDBM50524484(CHEMBL187262 | US12528773, Example NB-DNJ, miglust...)
Affinity DataIC50: 100nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 100 mM citric acid, 200 mM disodium phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2026
Entry Details
US Patent

TargetNon-lysosomal glucosylceramidase(Human)
University of Napoli Federico Ii

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50524484BDBM50524484(CHEMBL187262 | US12528773, Example NB-DNJ, miglust...)
Affinity DataIC50: 260nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed