BDBM50525144 CHEMBL4448933

SMILES Nc1ccccc1C(=O)N1CCC(CC1)N1CCC(Cc2ccc(cc2)S(=O)(=O)c2cccc(Cl)c2)CC1

InChI Key InChIKey=WIEMOFKMOGPXQF-UHFFFAOYSA-N

Data  12 KI  1 Koff

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50525144   

TargetMuscarinic acetylcholine receptor M2(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to human M2 receptor expressed in CHO-K1 cells incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-Scopolamine from human M2 receptor expressed in CHO cells assessed as inhibition constant measured for 120 mins by microplate be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
HUN-REN Research Centre for Natural Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  9.40nMAssay Description:Displacement of [3H]-Scopolamine from human M4 receptor expressed in CHO cells assessed as inhibition constant measured for 120 mins by microplate be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]-NMS from human muscarinic M5 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
HUN-REN Research Centre for Natural Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  91nMAssay Description:Displacement of [3H]-NMS from human muscarinic M4 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  119nMAssay Description:Displacement of [3H]-Scopolamine from human M5 receptor expressed in CHO cells assessed as inhibition constant measured for 120 mins by microplate be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
HUN-REN Research Centre for Natural Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  193nMAssay Description:Displacement of [3H]-Scopolamine from human M3 receptor expressed in CHO cells assessed as inhibition constant measured for 120 mins by microplate be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  324nMAssay Description:Displacement of [3H]-NMS from human muscarinic M1 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  425nMAssay Description:Displacement of [3H]-Scopolamine from human M1 receptor expressed in CHO cells assessed as inhibition constant measured for 120 mins by microplate be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
HUN-REN Research Centre for Natural Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKi:  676nMAssay Description:Displacement of [3H]-NMS from human muscarinic M3 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50525144BDBM50525144(CHEMBL4448933)
Affinity DataKon:  0.000867M-1s-1Assay Description:Competitive binding affinity to human M2 receptor expressed in HEK293T cells assessed as dissociation constant by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed