BDBM50526275 CHEMBL4515949
SMILES Clc1cc(NC2CCOCC2)c2ncc(-c3ccc4[nH]c(Nc5ccccc5)nc4c3)n2n1
InChI Key InChIKey=TWUAZGWGHKZNTE-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50526275
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) autophosphorylation at S724 after 25 mins in presence of ATP by dis...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) -dependent cleavage of FAM-labeled stem-loop RNA containing the XBP...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement for LanthaScreen tracer from dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) ATP binding site KEN domain after 60 mi...More data for this Ligand-Target Pair