BDBM50527628 CHEMBL4555432

SMILES CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CCc3ccc(cc3)C(=O)NO)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=BGEVIHODWMZVSQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50527628   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527628(CHEMBL4555432)
Affinity DataIC50: 5nMAssay Description:Inhibition of human PI3Kdelta assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527628(CHEMBL4555432)
Affinity DataIC50: 889nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1125 residues) expressed in baculovirus infected insect cells using fluorogenic pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527628(CHEMBL4555432)
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of recombinant C-terminal His-fusion tagged and N-terminal Streptavidin2-tagged human HDAC8 (1 to 377 residues) expressed in insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527628(CHEMBL4555432)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human recombinant N-terminal Streptavidin2-tagged HDAC11 (1 to 347 residues) expressed in baculovirus infected insect cells using fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527628(CHEMBL4555432)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human C-terminal His-fusion tagged HDAC5 (657 to 1123 residues) expressed in baculovirus infected insect cells using fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed