BDBM50528416 CHEMBL4440965

SMILES CNC(=O)C[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(F)c(F)c1

InChI Key InChIKey=SXDPQGRNHSLZPC-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50528416   

TargetRAC-beta serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of N-terminal GST-tagged human AKT2 (120 to 481 residues) expressed in baculovirus infected Sf21 cells incubated for 1 hr in presence of A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human Akt2 by mobile shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Akt3 (unknown origin) by mobile shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of human P70S6K by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50: 44nMAssay Description:Inhibition of Akt in human LNCaP cells assessed as reduction in PRAS40 phosphorylation at T246 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50: 64nMAssay Description:Inhibition of human ROCK1 by mobile shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50: 94nMAssay Description:Inhibition of PKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50: 131nMAssay Description:Inhibition of RSK1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50: 145nMAssay Description:Inhibition of human SGK by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed