BDBM50529036 CHEMBL4560892
SMILES OS(=O)(=O)c1cc(ccc1-c1ccc(F)cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O
InChI Key InChIKey=LCBYEMBRULUYAU-AREMUKBSSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50529036
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged Mcl-1 (E171 ti G327) expressed in Escherichia coli using biotin-labeled BIM peptide as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of recombinant human N-terminal 6xHis-tagged Bcl-w (M1 to R171) expressed in Escherichia coli using HyLite Fluor 647-labeled Bim peptide a...More data for this Ligand-Target Pair
Affinity DataEC50: >3.15E+4nMAssay Description:Inhibition of Bcl-xl in human U266B1 cells assessed as caspase 3/7 activation in presence of 10 % serum for 6 hrs by Caspase 3/7-Glo luminescence ass...More data for this Ligand-Target Pair
Affinity DataEC50: >3.15E+4nMAssay Description:Inhibition of Bcl-xl in human U266B1 cells assessed as caspase 3/7 activation for 6 hrs by Caspase 3/7-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.59E+4nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged Bcl-2 (M1 to F212 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM ...More data for this Ligand-Target Pair