BDBM50530239 CHEMBL4442335::US12053470, Compound 26

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(N)c(Sc3ccnc(C)c3Cl)c(=O)n2C)[C@@H]1N

InChI Key InChIKey=PMWMMYBAECEPMB-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50530239   

LigandPNGBDBM50530239(CHEMBL4442335 | US12053470, Compound 26)
Affinity DataIC50: 28nMAssay Description:Inhibition of SHP2 in human KYSE520 cells assessed as reduction in ERK phosphorylation after 2 hrs by SureFire p-ERK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530239(CHEMBL4442335 | US12053470, Compound 26)
Affinity DataIC50: 28nMAssay Description:Inhibition of SHP2 in human KYSE520 cells assessed as reduction in ERK phosphorylation after 2 hrs by SureFire p-ERK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530239(CHEMBL4442335 | US12053470, Compound 26)
Affinity DataIC50: 48nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
US Patent

LigandPNGBDBM50530239(CHEMBL4442335 | US12053470, Compound 26)
Affinity DataIC50: 48nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as surrogate substrate as preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530239(CHEMBL4442335 | US12053470, Compound 26)
Affinity DataIC50: 48nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as surrogate substrate as preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530239(CHEMBL4442335 | US12053470, Compound 26)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530239(CHEMBL4442335 | US12053470, Compound 26)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed