BDBM50530246 CHEMBL4471006::US10975080, Example 47

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4ccc(N)nc4C)c3c(=O)n2C)[C@@H]1N

InChI Key InChIKey=WUROOTMWWUJUGM-YVEFUNNKSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50530246   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  38nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  38nMAssay Description:Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  37nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  37nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human ERG by Q-patch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530246(CHEMBL4471006 | US10975080, Example 47)
Affinity DataIC50:  37nMAssay Description:Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed