BDBM50530618 CHEMBL4559807

SMILES COc1ccccc1-c1oc2ncnc(N[C@H](CO)c3ccccc3)c2c1-c1cccc(NC(=O)C=C)c1

InChI Key InChIKey=PDGXQCBYLSUPPW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50530618   

TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530618(CHEMBL4559807)
Affinity DataIC50: 0.145nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530618(CHEMBL4559807)
Affinity DataIC50: 0.145nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530618(CHEMBL4559807)
Affinity DataIC50: 0.636nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530618(CHEMBL4559807)
Affinity DataIC50: 0.636nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530618(CHEMBL4559807)
Affinity DataIC50: 24nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain (696 to 1022 residues) using poly(Glu, Tyr) 4:1 substrate incubated for 60 mins by kinase-Glo plus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530618(CHEMBL4559807)
Affinity DataIC50: 24nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain (696 to 1022 residues) using poly(Glu, Tyr) 4:1 substrate incubated for 60 mins by kinase-Glo plus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530618(CHEMBL4559807)
Affinity DataIC50: 157nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain I858R/T790M mutant (696 to 1022 residues) using EGFR L858R/T790M substrate peptide incubated for 12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530618(CHEMBL4559807)
Affinity DataIC50: 157nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain I858R/T790M mutant (696 to 1022 residues) using EGFR L858R/T790M substrate peptide incubated for 12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed