BDBM50530622 CHEMBL4514452

SMILES C[C@@H](Nc1ncnc2oc(c(-c3cccc(NC(=O)C=C)c3)c12)-c1ccccc1)c1ccccc1

InChI Key InChIKey=GRLBXHULTTZEJM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50530622   

TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530622(CHEMBL4514452)
Affinity DataIC50: 0.214nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530622(CHEMBL4514452)
Affinity DataIC50: 0.214nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530622(CHEMBL4514452)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530622(CHEMBL4514452)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530622(CHEMBL4514452)
Affinity DataIC50: 117nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain (696 to 1022 residues) using poly(Glu, Tyr) 4:1 substrate incubated for 60 mins by kinase-Glo plus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530622(CHEMBL4514452)
Affinity DataIC50: 117nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain (696 to 1022 residues) using poly(Glu, Tyr) 4:1 substrate incubated for 60 mins by kinase-Glo plus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530622(CHEMBL4514452)
Affinity DataIC50: 500nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain I858R/T790M mutant (696 to 1022 residues) using EGFR L858R/T790M substrate peptide incubated for 12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50530622(CHEMBL4514452)
Affinity DataIC50: 500nMAssay Description:Inhibition of GST-tagged human EGFR kinase domain I858R/T790M mutant (696 to 1022 residues) using EGFR L858R/T790M substrate peptide incubated for 12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed