BDBM50530783 CHEMBL4550310
SMILES O=C(CC#N)N1CCC[C@@H](C1)n1c2nc(Nc3ccc[nH]c3=O)ncc2[nH]c1=O
InChI Key InChIKey=UMELHOMADMVMKP-NSHDSACASA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50530783
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in Sf1 cells using PolyGT-Biotin as substrate measured af...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using PolyGT-Biotin as s...More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 (866 to 1154 residues) expressed in baculovirus expression system using PolyGT-Biotin as substrate me...More data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of JAK1/3 in human Ramos cells harboring beta-lactamase reporter gene assessed as reduction in IL4-induced STAT6 phosphorylation incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using PolyGT-Biotin as s...More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 (866 to 1154 residues) expressed in baculovirus expression system using PolyGT-Biotin as substrate me...More data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of JAK1/3 in human Ramos cells harboring beta-lactamase reporter gene assessed as reduction in IL4-induced STAT6 phosphorylation incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in Sf1 cells using PolyGT-Biotin as substrate measured af...More data for this Ligand-Target Pair