BDBM50530969 CHEMBL4537452

SMILES COc1ccc(c(F)c1)-c1cc(ncn1)N(Cc1ccccn1)Cc1ccccn1

InChI Key InChIKey=TZRMSEJLPYCPEI-UHFFFAOYSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50530969   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California-San Diego

Curated by ChEMBL
LigandPNGBDBM50530969(CHEMBL4537452)
Affinity DataEC50:  69nMAssay Description:Agonist activity at human alpha7 nAChR transfected in HEK cells assessed as increase in intracellular calcium release incubated for 30 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California-San Diego

Curated by ChEMBL
LigandPNGBDBM50530969(CHEMBL4537452)
Affinity DataEC50:  69nMAssay Description:Agonist activity at human alpha7 nAChR transfected in HEK cells assessed as increase in intracellular calcium release incubated for 30 mins in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California-San Diego

Curated by ChEMBL
LigandPNGBDBM50530969(CHEMBL4537452)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at -60 mV holding potential by tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California-San Diego

Curated by ChEMBL
LigandPNGBDBM50530969(CHEMBL4537452)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in channel currents at -60 mV holding potential by tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California-San Diego

Curated by ChEMBL
LigandPNGBDBM50530969(CHEMBL4537452)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as decrease in ACh-induced channel currents at -60 mV holding potential...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California-San Diego

Curated by ChEMBL
LigandPNGBDBM50530969(CHEMBL4537452)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as decrease in ACh-induced channel currents at -60 mV holding potential...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed