BDBM50531150 CHEMBL4460444

SMILES O=C(NCc1cc(F)cc(Cl)c1)[C@@]1(O)CCN(c2ccc3[nH]ncc3c2)C1=O

InChI Key InChIKey=RJYQONUBHSBQJP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50531150   

TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531150BDBM50531150(CHEMBL4460444)
Affinity DataIC50: 30nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531150BDBM50531150(CHEMBL4460444)
Affinity DataIC50: 30nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531150BDBM50531150(CHEMBL4460444)
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 2(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531150BDBM50531150(CHEMBL4460444)
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531150BDBM50531150(CHEMBL4460444)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal MetAP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMethionine aminopeptidase 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531150BDBM50531150(CHEMBL4460444)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal MetAP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed