BDBM50531292 CHEMBL4439933

SMILES COc1cc(Nc2cc(NC(=O)Nc3c(Cl)cccc3Cl)ncn2)cc(OC)c1

InChI Key InChIKey=ZOLGXEOLIHKKHY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50531292   

TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50531292(CHEMBL4439933)
Affinity DataIC50: 315nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669-1210 AA) expressed in baculovirus using FAM-labelled peptide as substrate pre-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50531292(CHEMBL4439933)
Affinity DataIC50: 315nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669-1210 AA) expressed in baculovirus using FAM-labelled peptide as substrate pre-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50531292(CHEMBL4439933)
Affinity DataIC50: 332nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR (d746-750AA) expressed in baculovirus using FAM-labelled peptide as substrate pre-incubated for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50531292(CHEMBL4439933)
Affinity DataIC50: 332nMAssay Description:Inhibition of N-terminal GST-tagged human EGFR (d746-750AA) expressed in baculovirus using FAM-labelled peptide as substrate pre-incubated for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50531292(CHEMBL4439933)
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus using FAM-labelled peptide as substrate pre-incubated for 10 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50531292(CHEMBL4439933)
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus using FAM-labelled peptide as substrate pre-incubated for 10 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50531292(CHEMBL4439933)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of N-terminal GST-tagged human FGFR1 cytoplasmic domain (398-822 AA) expressed in baculovirus using FAM-labelled peptide as substrate pre-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50531292(CHEMBL4439933)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of N-terminal GST-tagged human FGFR1 cytoplasmic domain (398-822 AA) expressed in baculovirus using FAM-labelled peptide as substrate pre-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed