BDBM50533253 CHEMBL4441232

SMILES COc1cc(ccc1CN)C(=O)N1C[C@H](C[C@H]1C(=O)N[C@H]1CCCC[C@@H]1c1ccccc1)n1cc(nn1)C1CC1

InChI Key InChIKey=AYVQDWAWTUYBGU-RVUATISTSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50533253   

TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of human f10aMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of human f10aMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Homo sapiens)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human chymotrypsinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50:  19nMAssay Description:Inhibition of human PRSS1 assessed as enzymatic cleavage of Benzoyl-GlyPro-Arg'Rh110-gammaGlu-OH by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50:  1.20E+4nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50:  1.20E+4nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Homo sapiens)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human chymotrypsinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533253(CHEMBL4441232)
Affinity DataIC50:  19nMAssay Description:Inhibition of human PRSS1 assessed as enzymatic cleavage of Benzoyl-GlyPro-Arg'Rh110-gammaGlu-OH by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed