BDBM50533577 CHEMBL1236131::US11459295, Compound (S) 4b

SMILES CSc1ccc2cc(ccc2c1)[C@H](C)C(O)=O

InChI Key InChIKey=DZFJDDMBLJXLJL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533577   

TargetAldo-keto reductase family 1 member C3(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandPNGBDBM50533577(CHEMBL1236131 | US11459295, Compound (S) 4b)
Affinity DataIC50: 70nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
US Patent

TargetAldo-keto reductase family 1 member C3(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandPNGBDBM50533577(CHEMBL1236131 | US11459295, Compound (S) 4b)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C2(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandPNGBDBM50533577(CHEMBL1236131 | US11459295, Compound (S) 4b)
Affinity DataIC50: 1.35E+3nMAssay Description:the inhibitory potency of the individual compounds against the AKR1C isoforms was determined by monitoring the NADP+ dependent oxidation of S-tetralo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
US Patent

TargetAldo-keto reductase family 1 member C2(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandPNGBDBM50533577(CHEMBL1236131 | US11459295, Compound (S) 4b)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human recombinant AKR1C2 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed