BDBM50533843 CHEMBL4469560

SMILES O=C1NCCC(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]1Cc1c[nH]c2ccccc12

InChI Key InChIKey=VTJCHLDYABYQLB-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533843   

TargetMu-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533843BDBM50533843(CHEMBL4469560)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533843BDBM50533843(CHEMBL4469560)
Affinity DataIC50: 6.10nMAssay Description:Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by EIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533843BDBM50533843(CHEMBL4469560)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50533843BDBM50533843(CHEMBL4469560)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]diprenorphine from human DOR expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed