BDBM50533859 CHEMBL4464132

SMILES Cc1c(N2CCN(Cc3ccc(cc3)C#N)CC2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F

InChI Key InChIKey=LBJZTOSGZWXDRK-LJAQVGFWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50533859   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533859(CHEMBL4464132)
Affinity DataIC50:  326nMAssay Description:Antagonist activity against human GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Sk Chemicals

Curated by ChEMBL
LigandPNGBDBM50533859(CHEMBL4464132)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]D-Trp6-LHRH from human GnRH receptor expressed in CHO-K1 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed