BDBM50534396 CHEMBL4562377

SMILES CNc1nc(cnc1-c1cccc(Cl)c1Cl)N1CCC(C)(N)CC1

InChI Key InChIKey=DKFJINZHYZDPBI-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50534396   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
TBA

Curated by ChEMBL

LigandBDBM50534396(CHEMBL4562377)Copy SMILESCopy InChI

Affinity DataIC50: 2.20E+4nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/25/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
TBA

Curated by ChEMBL

LigandBDBM50534396(CHEMBL4562377)Copy SMILESCopy InChI

Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human 6his-tagged SHP2 (2 to 593 residues) expressed in Escherichia coli BL21 Star (DE3) cells preincubated with IRS1_pY1172(dPEG8)pY12...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/28/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL