BDBM50534402 CHEMBL4459456

SMILES C[C@H]1CN(C[C@@H](C)N1)c1ncc(c(N)n1)-c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=MZGDRSYGPVIECI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50534402   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50534402(CHEMBL4459456)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of human 6his-tagged SHP2 (2 to 593 residues) expressed in Escherichia coli BL21 Star (DE3) cells preincubated with IRS1_pY1172(dPEG8)pY12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50534402(CHEMBL4459456)
Affinity DataIC50: 5.40E+4nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed