BDBM50535325 CHEMBL4437943

SMILES O=C(CCSC(=S)N1CCN(CC1)c1ccccc1)Nc1cccc(NC(=O)c2ccccn2)c1

InChI Key InChIKey=ZORWAVAQHOXTHK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50535325   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50: 54nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50: 94nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50: 3.12E+3nMAssay Description:Inhibition of human MER incubated for 90 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50: 1.79E+4nMAssay Description:Inhibition of human c-MET incubated for 2 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed